Chatterjee brings over 17 years of medical practice and medical research together with a historical and practical approach to overall health and well-being. Chatterjee doen't wait for the science to prove in all circumstances that something has a causation before implementing a number of practices with patients that he found have significantly improved their health and removed their pain and symptoms. The main components include relaxation, foods, movement, and sleep. These four pillars highlight the primary things we need to be doing to significantly improve our lives. As an over simplistic overview: The stress of our non-stop modern western lifestyle is killing us by constantly keeping the body in a physiological fight or flight response which doesn't provide it time to proper regeneration of cells or down time in which to do it. The processed foods we eat are basically poison that we were not genetically designed to eat and in our day we are eating larger quantities of poor quality food stuff rather than the right quantities of high quality natural food. Our lives have become increasingly more sedentary and that has limited our movement which is decreasing muscle mass and flexibility. The huge adaptation of electricity into society along with television and smart phones means we are never without electronic stimulus which has multiple negative effects, the greatest perhaps being the contributions to negative impact on sleep. We are sleeping less today on average than our ancestors did even 50 years ago and that difference matters in our body's ability to thrive. Running through all of these themes are the links between the physical food and movement and the mental and emotional impact the right lifestyle has on providing a well-balanced healthy life. Chatterjee argues and shows sufficient evidence that many of the pains, disease, and mental health challenges we face are a function of our modern lifestyle and can be remedied faster and more effectively by changing how we eat and how we live rather than a cocktail of medicines. The body is a complex organism that developed and adapted over hundreds of thousands and millions of years and no single piece of it can be cordoned off and treated independently like you would the parts to a car engine, if one part isn't doing the proper job it's going to negatively impact the rest and those parts will start to degrade as well when they have to perform functions they weren't designed for or at a capacity that exceeds the body's ability to regenerate new cells. I'm working to make significant changes based on information in this book and going to see if I can't eliminate many of the chronic pain that I have been experiencing the last few years.